Journal Publications
[J38]. Maruti J. Gurav, Prashantha Karunakar, Prasanna H. Megalamani, Kiran P C, Ashwini S. Sanji, J. Manasa, Devaraju Kuramkote Shivanna, Nilkamal Mahanta , Vishwanath B. Chachadi*, "Refining lectin specificity towards cancer-glycans: A computational approach to engineer lectins and their structural stability", In Silico Research in Biomedicine (Elsevier), 2025, (Article in Press). DOI:10.1016/j.insi.2025.100082 .
[J37]. Krushnamurthy Pattanayakanahalli Henjarappa, Simita Das, Dhananjaya G, Suvamay Jana and Nilkamal Mahanta*, "Pseudouridimycin Biosynthesis: Biochemical Characterization of the Glucose-Methanol-Choline (GMC) Family Oxidoreductase, PumI", Biochemistry (ACS publications), 2025, 64(17), 3718-3734. DOI:10.1021/acs.biochem.5c00177 . (* corresponding author).
[J36]. Lona M Alkhalaf, Cheryl Arrowsmith, Emily P Balskus, Giovanna Bergamini, Rashna Bhandari, Christopher J Chang, Peng Chen, Xing Chen, Alessio Ciulli, Julia A Cricco, Benjamin G Davis, Martina Delbianco, Natalia Dudareva, Erin Dueber, Fleur Ferguson, Priscila Oliveira de Giuseppe, Itaru Hamachi, Ming Chen Hammond, Stavroula K Hatzios, Won Do Heo, Jon Paul Janet, Siddhesh S Kamat, Stefan Knapp, Yamuna Krishnan, Kathrin Lang, Luca Laraia, Reuben B Leveson-Gower, Xiang David Li, David R Liu, Mo-Fang Liu, Nir London, Nilkamal Mahanta*, Cristina Mayor-Ruiz, Tom Muir, Mário Tyago Murakami, Hyun-Woo Rhee, Matt Robers, Alex Satz, Brenda A Schulman, Ben Shen, Brian Shoichet, Erick Strauss, Tsutomu Suzuki, Pratyush Tiwary, Herbert Waldmann, Thomas R Ward, Amy Weeks, Eranthie Weerapana, Georg Winter, "Thoughts for the future", Nature Chemical Biology, 2025, 21(1),6-15. DOI: 10.1038/s41589-024-01802-2.(* corresponding author)
[J35]. Dimple Saikia, Tanan Cebajel Bhanwarlal, Dhananjaya G, Basavaraj S Hungund, Nilkamal Mahanta, Surya P Singh*, "Validating phosphoethanolamine modification as a potential spectral marker of colistin resistance", Analyst (RSC Publications), 2025, 150, 281-289. DOI: 10.1039/D4AN01228C.
[J34]. Archana G. Revankar, Zabin K. Bagewadi *, Ibrahim Ahmed Shaikh, Dhananjaya G, Nilkamal Mahanta*, Aejaz Abdullatif Khan, Neha p. Bochageri, Basheerahmed Abdulaziz Mannasaheb, "Molecular analysis of recombinant collagenase from Bacillus siamensis strain Z1: Gene cloning, expression and in-silico characterization", Arabian Journal of Chemistry (Elsevier), 2024, 17 (9), 105942. DOI: 10.1016/j.arabjc.2024.105942. (* corresponding author).
[J33]. Zabin K. Bagewadi *, Gouri H. Illanad, Ibrahim Ahmed Shaikh, Mater H. Mahnashi, Shreya S. Shettar, Krushnamurthy P. H, Abdulfattah Yahya M. Alhazmi, Mohammed Ageeli Hakami, Nilkamal Mahanta*, Surya P. Singh, Jiro Karlo, Aejaz Khan, "Molecular expression, purification and structural characterization of recombinant L-Glutaminase from Streptomyces roseolus", International Journal of Biological Macromolecules (Elsevier), 2024, 273 (2), 133142. DOI: 10.1016/j.ijbiomac.2024.133142. (* corresponding author).
[J32]. Krushnamurthy P H, Simita Das, Nilkamal Mahanta*, "A new class of macrocyclic peptides", Nature Chemical Biology, 2024, 20, 136-139. DOI: 10.1038/s41589-023-01507-y. (* corresponding author).
[J31]. Simita Das, Krushnamurthy P H, Nilkamal Mahanta*, "Enzymatic reconstitution of salicylate formation in promysalin biosynthesis ", Bioorganic & Medicinal Chemistry Letters (Elsevier), 2023, 94, 129440. (* corresponding author). DOI: 10.1016/j.bmcl.2023.129440.
[J30]. Shreya S. Shettar, Zabin K. Bagewadi*, Deepak A. Yaraguppi, Simita Das, Nilkamal Mahanta, Surya P. Singh, Aditi Katti, Dimple Saikia, " Gene Expression and Molecular Characterization of Recombinant Subtilisin from Bacillus subtilis with Antibacterial, Antioxidant and Anticancer properties", International Journal of Biological Macromolecules (Elsevier), 2023, 249, 125960. DOI: 10.1016/j.ijbiomac.2023.125960.
[J29]. Tumpa Paul, Partha Pratim Saikia, Dhrubajit Borah*, Nilkamal Mahanta, Arabinda Baruah, Jayanta M Borah, Bhaskar J Saikia, Kalyan Raidongia, Raj Kumar Gogoi and Raktim Gogoi, "Ni(OH)2 nanoparticles as a recyclable catalyst in acceptorless dehydrogenation of alcohols to acids/acid salts under aerobic conditions", ChemistrySelect (Wiley), 2023, 8, issue 13. DOI: 10.1002/slct.202204713.
[J28]. Krushnamurthy P H, Subramanya K S, Simita Das, Dhananjaya G, Nilkamal Mahanta*, “Recent Advancements In Bottromycin Biosynthesis”, Synlett 2023, 34(07), 793-806. (* corresponding author). DOI: 10.1055/s-0042-1751373.
[J27]. Deepak A. Yaraguppi, Zabin K. Bagewadi*, Nilkamal Mahanta*, Surya Singh, T. M. Yunus Khan, Sanjay H. Deshpande, Chaitra Soratur, Simita Das, Dimple Saikia. “Gene Expression and Characterization of Iturin A Lipopeptide Biosurfactant from Bacillus aryabhattai for Enhanced Oil Recovery”, Gels 2022, 8(7), 403, 25 June 2022 . (* corresponding author). DOI: 10.3390/gels8070403.
[J26]. Douglas A. Mitchell, Timothy Precord, Graham Hudson, Nilkamal Mahanta, Brandon Bukhart, John Gerlt. “Radical SAM Enzymes and the Unexplored Chemistry of RiPP Biosynthesis”, The FASEB Journal ,36, issue S1, 2022. DOI: 10.1096/fasebj.2022.36.S1.0I185.
[J25]. Andi Liu, P.H.Krushnamurthy, K.S.Subramanya,Douglas A. Mitchell, Nilkamal Mahanta ★ ,“Enzymatic thioamidation of peptide backbones ”, Methods in Enzymology ,2021,(★ corresponding author) . DOI: 10.1016/bs.mie.2021.04.010.
[J24]. Andi Liu, Yuanyuan Si, Shi-Hui Dong, Nilkamal Mahanta, Haley N. Penkala, Satish K. Nair and Douglas A. Mitchell, “Functional elucidation of TfuA in peptide backbone thioamidation”, Nature Chemical Biology ,17, 585-592, 2021 March 11. DOI: 10.1038/s41589-021-00771-0.
[J23]. Timothy W. Precord, Nilkamal Mahanta, and Douglas A. Mitchell, “Reconstitution and substrate specificity of the thioether-forming radical S-adenosylmethionine enzyme in freyrasin biosynthesis”, ACS Chemical Biology , 14 (9), 2019, 1981-1989. DOI: 10.1021/acschembio.9b00457.
[J22]. Arun K. De, Ramachandran Muthiyan, Samiran Mondal, Nilkamal Mahanta , Jai Sunder, Debasis Bhattacharya, Anirudhha Banerjee, A. Kundu, Madhu S. Kundu, and S. Dam Roy. “A natural quinazoline derivative from marine sponge Hyrtios erectus induces apoptosis of breast cancer cells (MCF-7) via ROS production and intrinsic and extrinsic apoptosis pathways”, Marine drugs, 17(12), 2019, E658 (1-20). DOI: 10.3390/md17120658.
[J21]. Shi-Hui Dong, Andi Liu,Nilkamal Mahanta, Douglas A. Mitchell, and Satish K. Nair. “Mechanistic basis for ribosomal peptide backbone modifications”, ACS Central Science, 5 (5), 2019, 842-851. DOI: 10.1021/acscentsci.9b00124.
[J20]. Nilkamal Mahanta,# Katherine A. Hicks,# Saad Naseem, Yang Zhang, Dmytro Fedoseyenko, Steven E. Ealick, and Tadhg P. Begley. “Menaquinone Biosynthesis: Biochemical and structural studies of chorismate dehydratase”, Biochemistry, 58 (14), 2019, 1837-1840 (#co-first author). DOI: 10.1021/acs.biochem.9b00105.
[J19]. Nilkamal Mahanta,# D. Miklos Szantai-Kis,# E. James Petersson, and Douglas A. Mitchell. “Biosynthesis and chemical applications of thioamides’’, ACS Chemical Biology, 14 (2), 2019, 142-163, (#co-first author). DOI: 10.1021/acschembio.8b01022.
[J18]. Sumedh Joshi,# Dmytro Fedoseyenko,# Nilkamal Mahanta,# Rodrigo Ducati, Mu Feng, Vern Schramm, and Tadhg P. Begley. “Antibacterial strategy against H. pylori: Inhibition of the radical SAM enzyme MqnE in Menaquinone Biosynthesis”, ACS Medicinal Chemistry Letters, 10, 2019, 363-366 (#co-first author). DOI: 10.1021/acsmedchemlett.8b00649.
[J17]. Nilkamal Mahanta, Andi Liu, Shihui Dong, Satish K. Nair, and Douglas A. Mitchell. “Enzymatic reconstitution of ribosomal peptide backbone thioamidation”, Proceedings of the National Academy of Sciences, U.S.A., 115 (12), 2018, 3030-3035. DOI: 10.1073/pnas.1722324115.
[J16]. Mengxiao Liu, Guannan Zhang, Nilkamal Mahanta, Youngbok Lee, and Christian Hilty. “Measurement of kinetics and active site distances in metalloenzyme using paramagnetic NMR with 13C hyperpolarization”, Journal of Physical Chemistry Letters, 9 (9), 2018, 2218-2221. DOI: 10.1021/acs.jpclett.8b00350.
[J15]. Sumedh Joshi, Dmytro Fedoseyenko, Nilkamal Mahanta, and Tadhg Begley. “Aminofutalosine Synthase (MqnE): A new catalytic motif in radical SAM enzymology”, Methods in Enzymology, 606, 2018, 179. DOI: https://doi.org/10.1016/bs.mie.2018.05.002.
[J14]. Sumedh Joshi, Dmytro Fedoseyenko, Nilkamal Mahanta, Hannah Manion, Saad Naseem, Tohru Dairi, and Tadhg P. Begley. “Novel enzymology in futalosine-dependent menaquinone biosynthesis”, Current Opinion in Chemical Biology, 47, 2018, 134-141. DOI: 10.1016/j.cbpa.2018.09.015.
[J13]. Ramachandran Muthiyan, Nilkamal Mahanta, Balwin Nambikkairaj, Titus Immanuel, and Arun Kumar De. “Antioxidant and anti-inflammatory effects of a methanol extract from the marine sponge Hyrtios erectus”, Pharmacognosy magazine, 14 (58), 2018, 534-540. DOI: 10.4103/pm.pm_133_17.
[J12]. Nilkamal Mahanta, Zhengan Zhang, Graham Hudson, Wilfred van der Donk, and Douglas A. Mitchell. “Reconstitution and substrate specificity of the radical S-adenosyl-methionine thiazole C-methyltransferase in thiomuracin biosynthesis”, Journal of the American Chemical Society, 139 (12), 2017, 4310-4313. DOI: 10.1021/jacs.7b00693.
[J11]. Sumedh Joshi#, Nilkamal Mahanta#, Dmytro Fedoseyenko#, Howard Williams, and Tadhg P. Begley. “Aminofutalosine synthase: Evidence for captodative and aryl radical intermediates using beta-scission and SRN1 trapping reactions” Journal of the American Chemical Society, 139 (32), 2017, 10952-10955, (#co-first author). DOI: 10.1021/jacs.7b04209.
[J10]. Zhengan Zhang, Nilkamal Mahanta, Graham A. Hudson, Douglas A. Mitchell, and Wilfred A. van der Donk. “Mechanism of a class C radical S-adenosyl-L-methionine thiazole methyltransferase”, Journal of the American Chemical Society, 139 (51), 2017, 18623-18631. DOI: 10.1021/jacs.7b10203.
[J09]. Christopher J. Schwalen, Graham A. Hudson, Simone Kosol, Nilkamal Mahanta, Gregory L. Challis, and Douglas A. Mitchell. “In vitro biosynthetic studies of bottromycin expand the enzymatic capabilities of the YcaO superfamily”, Journal of the American Chemical Society, 139 (50), 2017, 18154-18157. DOI: 10.1021/jacs.7b09899.
[J08]. Nilkamal Mahanta, Graham A. Hudson, and Douglas A. Mitchell. “Radical S-adenosylmethionine enzymes involved in RiPP biosynthesis”, Biochemistry, 56 (40), 2017, 5229-5244. DOI: 10.1021/acs.biochem.7b00771.
[J07]. Dipti D. Nayak, Nilkamal Mahanta, Douglas A. Mitchell, and William W. Metcalf. “Post-translational thioamidation of methyl-coenzyme M reductase, a key enzyme in methanogenic and methanotrophic Archaea”, Elife, 6, 2017, e29218 (1-18). DOI: 10.7554/eLife.29218.001.
[J06]. Ramachandran Muthiyan, Balwin Nambikkairaj, Nilkamal Mahanta, Titus Immanuel, Kubendiran Kumaran, and Arun K. De. “Antiproliferative and proapoptotic activities of marine sponge Hyrtios erectus extract on breast carcinoma cell line (MCF-7)”, Pharmacognosy magazine, 13 (49), 2017, 41-47. DOI: 10.4103/0973-1296.203983.
[J05]. Zhengan Zhang, Graham A. Hudson, Nilkamal Mahanta, Jonathan I. Tietz, Wilfred A. van der Donk, and Douglas A. Mitchell. “Biosynthetic timing and substrate specificity for the thiopeptide thiomuracin”, Journal of the American Chemical Society, 138 (48), 2016, 15511-15514 (Chosen for JACS cover page). DOI: 10.1021/jacs.6b08987.
[J04]. Angad P. Mehta, Sameh H. Abdelwahed, Nilkamal Mahanta, Dmytro Fedoseyenko, Benjamin Philmus, Lisa E. Cooper, Yiquan Liu, Isita Jhulki, Steven E. Ealick, and Tadhg P. Begley. “Radical S-adenosylmethionine (SAM) enzymes in cofactor biosynthesis: a treasure trove of complex organic radical rearrangement reactions”, Journal of Biological Chemistry, 290 (7), 2015, 3980-3986. DOI: 10.1074/jbc.R114.623793.
[J03]. Nilkamal Mahanta, Dmytro Fedoseyenko, Tohru Dairi, and Tadhg P. Begley. “Menaquinone biosynthesis: formation of aminofutalosine requires a unique radical SAM enzyme”, Journal of the American Chemical Society, 135 (41), 2013, 15318-15321. DOI: 10.1021/ja408594p.
[J02]. Siyu Huang, Nilkamal Mahanta, Tadhg P. Begley, and Steven E. Ealick. “Pseudouridine monophosphate glycosidase: a new glycosidase mechanism”, Biochemistry, 51 (45), 2012, 9245-9255. DOI: 10.1021/bi3006829.
[J01]. Nilkamal Mahanta, Anshu Gupta, and Sunil K. Khare. “Production of protease and lipase by solvent tolerant Pseudomonas aeruginosa PseA in solid-state fermentation using Jatropha curcas seed cake as substrate”, Bioresource Technology (Elsevier), 99 (6), 2008, 1729-1735. DOI: 10.1016/j.biortech.2007.03.046.
Book Chapters
[B03]. Dhananjaya G#, Krushnamurthy P H#, Simita Das# , Nilkamal Mahanta* . “Functional role and therapeutic prospects of phospholipases in infectious diseases" in Phospholipases in Physiology and Pathology: Therapeutics of Natural and Synthetic Compounds in Phospholipases Induced Diseases, , edited by Prof. Sajal Chakraborti, publisher: Elsevier, USA, 2023, 5, 39-51. DOI: 10.1016/B978-0-323-95699-4.00010-4 (# Equal contribution; * Corresponding author).
[B02]. Simita Das#, Krushnamurthy P H#, Dhananjaya G#, Nilkamal Mahanta* . “Functional role of phospholipase D in apoptosis and cancer" in Phospholipases in Physiology and Pathology, publisher: Elsevier, USA, 2023, 4, 253-267. DOI: 10.1016/B978-0-323-95698-7.00007-3 (# Equal contribution; * Corresponding author).
[B01]. Krushnamurthy P H#, Simita Das#, Dhananjaya G#, Nilkamal Mahanta* . “Therapeutic implications of piperlongumine” in Handbook of oxidative stress in cancer:Therapeutic aspects , publisher: Springer Nature,2022, 1-22. DOI: 10.1007/978-981-16-1247-3_190-1. (# Equal contribution; * Corresponding author).
Conference proceedings
[C4]. Nilkamal Mahanta, Dipti Nayak, Andi Liu, Shihui Dong, Satish Nair, William Metcalf, and Douglas A. Mitchell. “Post-translational thioamidation of methyl-coenzyme M reductase, a key enzyme in the global carbon cycle”, Abstracts of papers of the American Chemical Society (American Chemical Society Publication), 255, 2018.
[C3]. Nilkamal Mahanta, Zhengan Zhang, Graham A. Hudson, Wilfred A. van der Donk, and Douglas A. Mitchell. “Substrate specificity and mechanism of a class C radical SAM thiazole methyltransferase”, Abstracts of papers of the American Chemical Society (American Chemical Society Publication), 255, 2018.
[C2]. Nilkamal Mahanta, Zhengan Zhang, Graham A. Hudson, Wilfred A. van der Donk, and Douglas A. Mitchell. “Studies on the radical S-adenosyl-methionine (SAM) thiazole C-methyltransferase involved in thiomuracin biosynthesis”, Abstracts of papers of the American Chemical Society (American Chemical Society Publication), 254, 2017.
[C1]. William W. Metcalf, Dipti D. Nayak, Nilkamal Mahanta, Douglas A. Mitchell. “Post-translational thioamidation of methyl-coenzyme M reductase, a key enzyme in methanogenic and methanotrophic Archaea”, bioRxiv (Cold Spring Harbor Laboratory), 121111, 2017.DOI: 10.1101/121111.
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